Friday, December 13, 2019

Hemoglobin Model Free Essays

Hemoglobin model: note the 02 being carried by molecule. Pipe cleaners=subunits Green marsh mellow=iron molecule Yellow marsh mellow=oxygen molecule Orange cards= heme groups (wolfe, 2000) Oxygenated/deoxygenated oxygenated †¢ 02 bound †¢ Bright red †¢ Subunit is in relaxed form †¢ Higher affinity for 02 †¢ Affinity for oxygen is  cooperative, which means  that the affinity for 02  increases with each bound  molecule. ( Ahern Rajagopal, 2013) Deoxygenated †¢ 02 not bound †¢ Dark red color †¢ In tense form which has lower affinity for oxygen. We will write a custom essay sample on Hemoglobin Model or any similar topic only for you Order Now †¢ When 02 binds to  deoxygenated hemoglobin,  hemoglobin transitions from T  state to R state. This occurs  when 02 binds to iron, it  causes a change in the  subunit. ( Ahern Rajagopal,  2013) Bohr Effect Hemoglobin has a high affinity for 02 at a high PH, low Co2. Hemoglobin has a lower affinity at a low PH, high Co2.  At a high Co2, low PH hemoglobin is more stable in the T state which decreases its affinity for 02. Oxygen needs to be delivered to the tissues. Tissues have a low PH. Hemoglobin needs to release 02 at low PH. Low PH = low 02 saturation.  ( Wolfe,2000 ) Myoglobin: wants to store 02 for when tissues need it. Has a higher affinity than hemoglobin. ( Ahern Rajagopal, 2013) Hemoglobin: wants to unload 02 in the tissues. Has a lower affinity than myoglobin. ( Ahern Rajagopal, 2013 )  (Genetic science learning center, 2013) Difference between normal and sickle forms of hemoglobin. Normal and sickle RBC’s at the cellular level.  (Genetic science learning center, 2013) Diseased RBC’s vs. Normal RBC’s Diseased †¢ Have a sickle shape, and are  thick and sticky. Clumps  together in small blood  vessels. †¢ Blocks normal hemoglobin  to deliver 02 to tissues. †¢ Short life span of 10-20 days †¢ Body can not keep up with rbc production leading to  anemia and pain. (Wolfe,  2000) Normal †¢ Round †¢ Doughnut shape †¢ Life span of 120 days (Wolfe, 2000)  (Ahern and Rajagopal, 2013) How to cite Hemoglobin Model, Papers

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